The City of Florence, Kentucky, has a traditional Main Street that it is focused on activating through dedicated management, redevelopment of key properties, street improvements, and investments in infrastructure. As it pursues these initiatives, the City sought to amplify the private investment return on this work through a revised Florence Main Street (FMS) Zoning District and district boundary that removes barriers to creative investment, rehabilitation of structures, and new infill development. The Florence Main Street Activation Guide provides a decision-making framework for Boone County staff that oversees the City’s zoning and site plan approvals to approve or deny Zoning Permits. More than a passive document, it provides a tailored set of recommendations that will actively shape growth within the expanded Main Street District.